Background:  The connexin family of proteins form hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences between connexins arise from specific amino acid substitutions in the most highly conserved domains: the transmembrane and extracellular regions. Connexin 59, also known as connexin 58, GJA9 (Gap junction alpha-9 protein) or GJA10 (Gap junction alpha-10 protein), is a 515 amino acid multi-pass membrane protein that belongs to the connexin family. Localized to the cell membrane and to gap junctions, connexin 59 functions as part of a connexon complex through which low molecular weight materials diffuse from one cell to another.

Description: Rabbit polyclonal to Connexin 59

Immunogen: KLH conjugated synthetic peptide derived from Connexin 59

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 59 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.