Background:  The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.9, also known as GJD3 (Gap junction delta-3 protein), is a 294 amino acid protein that interacts with ZO-1, a tight junction protein. Connexin 31.9 is expressed in heart, brain, kidney, spleen, lung, testis, colon and vascular smooth muscle cells. There are two isoforms of connexin 31.9 that are produced as a result of alternative splicing events.

Description: Rabbit polyclonal to Connexin 31.9

Immunogen: KLH conjugated synthetic peptide derived from Connexin 31.9

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.