Background:  SAMD3 (sterile α motif domain-containing protein 3) is a 520 amino acid protein that contains one SAM (sterile alpha motif) domain. Existing as two alternatively spliced isoforms, the SAMD3 gene is conserved in chimpanzee, canine, bovine and mouse, and maps to human chromosome 6q23.1. The medulloblastoma cell line DAOY has a homozygous deletion on chromosome 6 that disrupts three genes: SAMD3, L3MBTL3 and TMEM200A. This region of chromosome 6 has been identified as a significant region of loss in medulloblastoma. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. A bipolar disorder susceptibility locus has also been identified on the q arm of chromosome 6.

Description: Rabbit polyclonal to SAMD3

Immunogen: KLH conjugated synthetic peptide derived from SAMD3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 61 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.