Background:  Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking. Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP. In mammals, there exist two major isoforms, Rab GDI alpha (also known as XAP-4) and Rab GDI beta. While the mammalian Rab GDI beta-genes are ubiquitously expressed, the Rab GDI å genes are predominantly brain-specific. Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission. The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms.

Description: Rabbit polyclonal to GDI1

Immunogen: KLH conjugated synthetic peptide derived from GDI1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 51 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.