Background:  CUEDC2 (CUE domain containing 2), also known as HOYS6, is a 287 amino acid cytoplasmic and nuclear protein that contains one CUE domain, which it utilizes to interact with both PR and ERα, thereby influencing their protein expression levels by marking them for proteasomal degradation. A member of the CUEDC2 family, CUEDC2 also targets IKK for inactivation by PP1 recruitment. The gene encoding CUEDC2 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.

Description: Rabbit polyclonal to CUEDC2

Immunogen: KLH conjugated synthetic peptide derived from CUEDC2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 32 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.