Background:  FPGS is a 587 amino acid protein that localizes to both the nucleus and the cytoplasm in an isoform-dependent manner and is involved in tetrahydrofolylpolyglutamate biosynthesis. Existing as a monomer, FPGS catalyzes the ATP-dependent conversion of folates to polyglutamate derivatives, thus allowing tissues to have a higher concentration of folate than the surrounding plasma. The gene encoding FPGS maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Description: Rabbit polyclonal to FPGS

Immunogen: KLH conjugated synthetic peptide derived from FPGS

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 65 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.