Background:  TAF1 is the largest component and core scaffold of the TFIID basal transcription factor complex. It contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. TAF1 phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. It possesses DNA-binding activity. It is essential for progression of the G1 phase of the cell cycle. Defects in TAF1 are the cause of dystonia type 3 (DYT3) which also called X-linked dystonia-parkinsonism (XDP).

Description: Rabbit polyclonal to TAF1

Immunogen: KLH conjugated synthetic peptide derived from TAF1

Specificity:  ·Reacts with Human, Mouse, Rabbit and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 212 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-100;

·Immunocytochemistry: 1/100;

·Optimal working dilutions must be determined by the end user.