Background:  The human RFamide-related peptide gene, RFRP (also designated NPVF or C7orf9), is responsible for encoding three small neuropeptides designated RFRP-1 (NPSF), RFRP-2 and RFRP-3 (NPVF). The homologous gene in rodents encodes only two functional neuropeptide: RFRP-1 (NPSF) and RFRP-3 (NPVF). RFamide-related peptides constitute a large family of neuropeptides in a wide range of species that are known to play a role in neurotransmission, neuromodulation, cardioexcitation and control of muscle contraction. Neuropeptides RFRP-1 and RFRP-3 efficiently inhibit Forskolin-induced production of cAMP. RFRP-2, however, does not appear to have a similar inhibitory activity. RFamide-related peptides are secreted and abundantly expressed in retina. RFRP-1 and RFRP-3 are also widely distributed in fetal and adult brain, including the forebrain, hypothalamus, thalamus, midbrain, pons and medulla oblongata. RFRP-1 and the prolactin (PRL)-releasing peptide-31 (PrRP-31) may be involved in the stimulation of stress hormone secretion by either direct pituitary or indirect hypothalamic actions.

Description: Rabbit polyclonal to RFRP-3

Immunogen: KLH conjugated synthetic peptide derived from RFRP-3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 25 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-100;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.