Background:  Sclerosteosis (SOST), an autosomal recessive sclerosing bone dysplasia, and Van Buchem disease, a closely related disorder, cause massive bone overgrowth. SOST is associated with mutations in the SOST gene and leads to gigantism, entrapment of the seventh and eighth cranial nerves and possibly also distortion of the facies. Van Buchem disease is associated with a 52 kb deletion downstream of the SOST gene that probably affects transcription of the gene. Sclerostin, the protein encoded by the SOST gene, is important for bone homeostasis. It is a secreted protein that inhibits bone formation. Sclerostin is generally expressed at low levels, but high expression of Sclerostin can be detected in bone, cartilage, liver, bone marrow and kidney tissue.

Description: Rabbit polyclonal to Sclerostin

Immunogen: KLH conjugated synthetic peptide derived from Sclerostin

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 24 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.