Background:  Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha IIB/beta 3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha IIB/beta 3 and alpha V/beta 3 recognise the sequence R G D in a wide array of ligands. Integrin alpha IIB/beta 3 recognises the sequence H H L G G G A K Q A G D V in fibrinogen gamma chain. Following activation integrin alpha IIB/beta 3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Description: Rabbit polyclonal to Integrin Alpha 3 + Beta 1

Immunogen: KLH conjugated synthetic peptide derived from Integrin Alpha 3 + Beta 1

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 115 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/100-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.