Background:  DMT1 ("divalent metal transporter 1") is a transporter involved in human iron metabolism. It is located on the apical membrane of duodenal enterocytes and transports Fe2+ from the intestinal lumen to the cytosol. Dietary iron must be reduced from Fe3+ to Fe2+ before being transported by DMT1. This is accomplished by Duodenal cytochrome B. DMT1 is a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2.

Description: Rabbit polyclonal to DMT1

Immunogen: KLH conjugated synthetic peptide derived from DMT1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/200-500. Predicted Mol wt: 62 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/200;

·ELISA: 1/1000;

·Optimal working dilutions must be determined by the end user.