Background:  Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. SERHL (serine hydrolase-like) also known as SERHL2 (serine hydrolase-like 2) is a ubiquitously expressed 314 amino acid member of the AB hydrolase superfamily. Localized to peroxisomes and to the perinuclear region of the cytoplasm, SERHL is thought to be involved in muscle hypertrophy, a phenomenon characterized by growth and increase in size of muscle cells in response to mechanical stress or passive stretch. SERHL is a probable serine hydrolase that is expressed at normal levels during muscle development and is overexpressed in response to skeletal muscle stretch in vivo. Expression of SERHL is upregulated in breast cancer cells, suggesting a possible role in carcinogenesis. Three isoforms exist due to alternative splicing events. SERHL2 (serine hydrolase-like 2) shares high homology with SERHL and is thought to be expressed by a gene which may be a duplicate of the gene encoding SERHL.

Description: Rabbit polyclonal to SERHL2

Immunogen: KLH conjugated synthetic peptide derived from SERHL2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 35 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.