Background:  Tankyrase 2 possess 24 ankyrin-type repeats, a sterile alpha motif, and a C-terminal poly(ADP-ribose) polymerase (PARP) homology domain. Tankyrase 2 poly(ADP-ribosyl)ated itself and TRF1 and therefore may contribute to the regulation of telomere length. It may also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Tankyrase 2 is highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Tankyrase 2 is found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of Tankyrase 2 is found in the nucleus, associated with TRF1.

Description: Rabbit polyclonal to Tankyrase 2

Immunogen: KLH conjugated synthetic peptide derived from Tankyrase 2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 127 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.