Background:  MSH5 (mutS homolog 5 (E. coli)), also known as G7, NG23 or MutSH5, is an 834 amino acid protein that belongs to the mutS family of DNA mismatch repair proteins. Expressed ubiquitously with highest expression in thymus and testis, MSH5 exists as a heterooligomer with MSH4 and is involved in meiotic recombination, specifically functioning to facilitate homologous crossovers during meiosis. Multiple isoforms of MSH5 exist due to alternative splicing events. The gene encoding MSH5 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Description: Rabbit polyclonal to MSH5

Immunogen: KLH conjugated synthetic peptide derived from MSH5

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 93 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.