Background:  SNM1 is a DNA-crosslink repair protein. SNM1 is the human homolog of a gene first identified in Drosphilia melanogaster and Saccharomyces cerevisiae. SNM1 mutants of Saccharomyces cerevisiae have been shown to be specifically sensitive to DNA interstrand crosslinking agents but not sensitive to monofunctional alkylating agents, UV, or ionizing radiation. To date, 5 homologs of Snm1 have been identified in the mammalian genome and are termed SNM1, SNM1B, Artemis, ELAC2, and CPSF73. Human SNM1 localizes to the cell nucleus in three distinct patterns: diffuse nuclear staining, multiple nuclear foci, or one or two larger bodies confined to the nucleus. Research suggests a function for human Snm1 in the cellular response to double-strand breaks formed by ionizing radiation and interstrand crosslinking agents.

Description: Rabbit polyclonal to SNM1

Immunogen: KLH conjugated synthetic peptide derived from SNM1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 23 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.