Background:   YMER, also known as CCDC50 (coiled-coil domain containing 50), C3orf6 or DFNA44, is a 306 amino acid cytoplasmic protein that exists as two alternatively spliced isoforms involved in EGFR signaling. YMER isoforms 1 and 2 (also designated isoforms short and long) are co-expressed in pancreas, placenta, liver, lung and kidney, but only isoform 1 is found at high levels in heart, brain and skeletal muscle. Containing multiple ubiquitin-interacting domains as well as tyrosine-phosphorylated residues, YMER negatively regulates NF˚B. The gene encoding YMER maps to human chromosome 3q28, and, when defective, is the cause of a form of hearing loss known as deafness autosomal dominant type 44 (DFNA44).

Description: Rabbit polyclonal to CCDC50

Immunogen: KLH conjugated synthetic peptide derived from CCDC50

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 36 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.