Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of cysts in kidney tubules as well as in liver and pancreas tissues. Cells within these cysts display abnormalities in proliferation and polarity. Polycystin-2 (PKD2), an integral membrane glycoprotein, is mutated in approximately 15% of patients with ADPKD. Polycystin-2 is expressed in medullary collecting ducts, cortical collecting ducts and distal convoluted tubules of kidney. It associates with Hax-1 and may be involved in cell-matrix interactions. Polycystin-1 and Polycystin-2 display significant homology within their transmembrane region and are thought to interact in order to enhance AP-1 expression, which regulates cell proliferation, differentiation and apoptosis. These findings suggest that mutations in Polycystin-2 may facilitate the development of renal tubular cysts.

Description: Rabbit polyclonal to Polycystin 2

Immunogen: KLH conjugated synthetic peptide derived from Polycystin 2

Specificity:  ·Reacts with Human, Mouse, Chicken, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 110 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.