Background:  This protein contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of Synphilin 1 have been linked to Parkinson disease. Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.

Description: Rabbit polyclonal to Synphilin 1

Immunogen: KLH conjugated synthetic peptide derived from Synphilin 1

Specificity:  ·Reacts with Human, Mouse, Pig, Dog, Chicken and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 100 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.