Background:  The BTB (broad-complex, tramtrack and bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD7 (BTB/POZ domain-containing protein 7), also known as FUP1 (function unknown protein-1), is a 1,132 amino acid protein involved in tumor formation and stimulation of cell proliferation. BTBD7 contains two BTB (POZ) domains and is implicated in the formation of branched organs such as salivary glands and lung. Existing as five alternatively spliced isoforms, the gene encoding BTBD7 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer’s disease (AD).

Description: Rabbit polyclonal to BTBD7

Immunogen: KLH conjugated synthetic peptide derived from BTBD7

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 126 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.