Background:  Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones.

Description: Rabbit polyclonal to TRH Receptor

Immunogen: KLH conjugated synthetic peptide derived from TRH Receptor

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.