Background: GLYAT (glycine-N-acyltransferase), also known as GAT, CAT, HRP-1(CLP), Acyl-CoA:glycine N-acyltransferase (AAc) or ACGNAT, is a 296 amino acid mitochondrial acyltransferase that conjugates glycine to acyl-CoA substrates. Existing as two alternatively spliced isoforms, GLYAT may participate in detoxification of endogenous and xenobiotic acyl-CoA and is expressed in human liver at peak levels from 18 months to 40 years. Children under 7 months express only five to forty percent of liver GLYAT specific activity, thereby functioning with a lower ability to detoxify their system of certain drugs and xenobiotics. A member of the glycine N-acyltransferase family, GLYAT is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Description: Rabbit polyclonal to GLYAT

Immunogen: KLH conjugated synthetic peptide derived from GLYAT

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 34 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.