Background:  UIP1 (UCHL5-interacting protein, HAUS augmin-like complex subunit 7) is a 368 amino acid product of the human HAUS7 gene. UIP1 is subunit 7 of the HAUS augmin-like complex, which is involved with regulation of spindle assembly during mitosis and contributes to the integrity of the centrosome. The HAUS augmin-like complex associates with the γ-tubulin ring complex. This interaction is required for spindle assembly. UIP1 also binds to UCHL5(ubiquitin carboxyl-terminal hydrolase isozyme L5) which is a protease that specifically cleaves ‘Lys-48’-linked polyubiquitin chains. UIP1 localizes to the centrosome during interphase and becomes part of the spindle microtubules during mitosis. Detectable levels of expression have been found in spleen, thymus, testis, ovary, small intestine and colon tissues.

Description: Rabbit polyclonal to UCHL5IP

Immunogen: KLH conjugated synthetic peptide derived from UCHL5IP

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.