Background:  Synaptotagmin X, also known as SytX or synaptotagmin-10 (SYT10), is a 523 amino acid single-pass synaptic vesicle membrane protein that belongs to the synaptotagmin family and contains 2 C2 domains. Three calcium ions are bound to Synaptotagmin X per subunit using the C2 domains. While it may be involved in calcium-dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain, Synaptotagmin X may also serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin X exists as either a homodimer or heterodimer and is only expressed in pancreas, lung and kidney. The gene that encodes Synaptotagmin X contains 64,407 bases and maps to human chromosome 12p11.1. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Description: Rabbit polyclonal to Synaptotagmin 10

Immunogen: KLH conjugated synthetic peptide derived from Synaptotagmin 10

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 59 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.