Background:  Akirin2, also known as C6orf166, is a 203 amino acid nuclear protein belonging to the Akirin family. Widely expressed, with highest levels in peripheral blood leukocytes, Akririn2 is a downstream effector of the TNF, IL-1 and TLR signaling pathways which lead to the production of IL-6. Akirin2 also interacts with 14-3-3 to form a complex which represses the transcription of MKP-1. The gene that encodes Akirin2 maps to human chromosome 6. Chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus.

Description: Rabbit polyclonal to Akirin2

Immunogen: KLH conjugated synthetic peptide derived from Akirin2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 22 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.