Background:  WRB, also known as congenital heart disease 5 protein (CHD5), is a 174 amino acid nuclear protein that has a potential nuclear localization signal and a tryptophan-rich C-terminus. Widely expressed in both adult and fetal tissues, WRB is encoded by a gene that localizes to a region on chromosome 21 that is associated with congenital heart disease (CHD) in Down syndrome (DS) patients. DS, a chromosomal disorder caused by an extra copy of chromosome 21, is characterized by poor muscle tone, impaired cognitive ability, retarded physical growth and an increased risk for CHD. Due to its location on chromosome 21, WRB may be involved in the pathogenesis of DS-related heart disease.

Description: Rabbit polyclonal to WRB

Immunogen: KLH conjugated synthetic peptide derived from WRB

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 20 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.