Background:  GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid protein encoded by the human gene GRASP. GRASP is a scaffold protein that comprises multiple protein-interacting domains, including a postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper region, and a carboxyl-terminal PDZ binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP form a heteromer composed of GRASP, PSCD2 and at least one mGluR1. It also interacts with PSCD3, mGluR2, mGluR3 and mGluR5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney, and ovary.

Description: Rabbit polyclonal to GRASP

Immunogen: KLH conjugated synthetic peptide derived from GRASP

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.