Background:  The Nirs (Nir1, Nir2, and Nir3), human homologues of Drosophila retinal degeneration B (rdgB), have been considered candidate genes for human inherited retinal degeneration diseases. The three Nir proteins are highly expressed in the developing retina, each exhibiting a distinct distribution profile. Nir3 (phosphatidylinositol transfer protein, membrane-associated 2), also known as membrane-associated phosphatidylinositol transfer protein 2, PYK2 N-terminal domain-interacting receptor 3, PITPNM2, RDGB2, RDGBA2 or KIAA1457, is a 1,349 amino acid protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Nir3 is highly expressed in thymus, heart, ovary, testis and brain, and is expressed at lower levels in prostate, pancreas, small intestine, skeletal muscle, liver, placenta and colon. Three Nir3 isoforms exist as a result of alternative splicing, and Nir3 contains one DDHD domain. The gene encoding Nir3 maps to human chromosome 12q24.31.

Description: Rabbit polyclonal to NIR3

Immunogen: KLH conjugated synthetic peptide derived from NIR3

Specificity:  ·Reacts with Human, Mouse, Pig and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 148 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.