Background:  Neuroguidin (NGD), also known as eIF4E-binding protein, NGDN, LCP5 or lpd-2, is a 315 amino acid protein that interacts with eIF4E and CPEB, and plays a role in cytoplasmic polyadenylation element (CPE)-containing mRNA translational repression. A member of the SAS10 family, neuroguidin exists as two alternatively spliced isoforms and localizes to cytoplasm, nucleus and cell projections of axons, dendrites and filopodia. Neuroguidin may play a role in the development of the vertebrate nervous system via transcriptional regulation. Neuroguidin is expressed in brain, kidney, spleen, ovary and testis, and is encoded by a gene that maps to human chromosome 14q11.2. Chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD).

Description: Rabbit polyclonal to Neuroguidin

Immunogen: KLH conjugated synthetic peptide derived from Neuroguidin

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 36 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.