Background: RBM9 is a 390 amino acid protein that contains one RRM (RNA recognition motif) domain. RBM9 is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. RBM9 regulates the splicing activity of the highly conserved RNA 5'-UGCAUGU-3' element, an intron splicing enhancer that is often located adjacent to tissue-specific alternative exons. RBM9 prevents binding of U2AF65 (U2 snRNP auxiliary factor large subunit) to the 3' splice site of the RNA splicing element which affects alternative splicing of tissue-specific exons. RBM9 also interacts with the ERa (estrogen receptor alpha) transcription factor and regulates ERa transcriptional activity. Eight isoforms of RBM9 exists due to alternative splicing events.

Description: Rabbit polyclonal to RBM9

Immunogen: KLH conjugated synthetic peptide derived from RBM9

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.