Background:  QK1 is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QK1 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, QK1 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QK1 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QK1 mRNA-binding affinity. Defects or deletions in the gene encoding QK1 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QK1 exist due to alternative splicing events.

Description: Rabbit polyclonal to QK1

Immunogen: KLH conjugated synthetic peptide derived from QK1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 37 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.