Background: C4-binding protein (C4BP) is a multimeric protein, synthesised in the liver. The most abundant form consists of seven alpha-chains (70kDa) and one beta-chain (45kDa) all linked by disulphide bonds to form the native protein with a molecular weight of 570kDa. It is is a plasma protein with a concentration of about 150mg/L in normal plasma. It is a component of the classical complement pathway. C4BP down regulates complement activity in two ways, it binds to C4b thus inhibiting the formation of C3-convertase (C4bC3a) and it accelerates the decay of existing convertases. C4BP acts as a cofactor in Factor I mediated C4b proteolysis. C4BP may also have a regulatory role in the coagulation system, by binding to Protein S. When bound toC4BP, Protein S is inactive.

Description: Rabbit polyclonal to C4BP

Immunogen: KLH conjugated synthetic peptide derived from C4BP

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 70 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.