Background: BEND6 (BEN domain-containing protein 6) is a 279 amino acid protein that contains a BEN domain. BEND6 exists as four alternatively spliced isoforms and is considered a complete proteome. BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. BEN domain may play a role in organization of viral DNA during replication or transcription. The BEND6 gene maps to chromosome 6p12.1. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated，predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6.

Description: Rabbit polyclonal to BEND6

Immunogen: KLH conjugated synthetic peptide derived from BEND6

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 31 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.