Background: MIG7 is a cysteine-rich protein found in cell membranes and cytoplasm of carcinoma cells. Tumor tissue and blood from over 200 cancer patients have been shown to express MIG7, regardless of tissue origin. In contrast, it has not been detectable in tissues or blood from normal subjects. Expression of MIG7 seems to be restricted to carcinoma cells and putatively to the early placenta (Cytotrophoblast) and it's expression is important for the invasive capabilities of tumor cells. MIG7 seems to be a promising cancer cell marker for the detection of migrating and circulating carcinoma cells, the detection of occult tumor cells, and for diagnosis and disease progression. In vivo, MIG7 may be a carcinoma-specific target to potentially inhibit tumour invasion and vasculogenic mimicry, thereby preventing growth of tumors and dissemination of tumor cells.

Description: Rabbit polyclonal to MIG7

Immunogen: KLH conjugated synthetic peptide derived from MIG7

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 23 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.