Background: CPB (carboxypeptidase B), also known as CPB1, PASP (pancreas-specific protein) or PCPB, is a zinc-containing exopeptidase belonging to the A/B subfamily (or peptidase subfamily M14 A) of carboxypeptidases. CPB functions as a digestive carboxypeptidase and cleaves C-terminal basic amino acid residues from substrates. CPB is synthesized as an inactive zymogen in the endoplasmic reticulum of pancreatic acinar cells. It is then packaged into secretory granules and secreted into the lumen upon acinar cell stimulation. In the duodenum, CPB is activated by the cleavage of its N-terminal activation peptide (also known as CAPAP). CPB is widely recognized as a useful serum marker for acute pancreatitis and pancreatic graft rejection.

Description: Rabbit polyclonal to CPB1

Immunogen: KLH conjugated synthetic peptide derived from CPB1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.