Background:  Dlx genes are a highly conserved family of six different (Dlx1-6) homeobox-containing genes that share homology with distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. Dlx-1 (distal-less homeobox 1), also known as Distal-less, is a 255 amino acid protein that is essential for progenitors to differentiate into GABAergic (secreting or transmitting of γ-aminobutyric acid) neurons. Dlx proteins influence different stages of proper tissue development, including patterning of the orofacial skeleton (craniofacial ectomesenchyme) and differentiation of structures within and between teeth. Dlx-1 is expressed in spatially and temporally restricted patterns in craniofacial primordia, basal telencephalon and diencephalon, and in distal regions of extending appendages, including the limb and the genital bud. The differential expression of Dlx-1 influences patterning, morphogenesis and histogenesis in these tissues. Due to its ability to influence transcription, Dlx-1 is thought to regulate a transcriptional hierarchy that controls neuron versus oligoden-droglial cell fate within a progenitor.

Description: Rabbit polyclonal to DLX1

Immunogen: KLH conjugated synthetic peptide derived from DLX1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 27 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.