Background:  The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM2 (tripartite motif-containing 2), also known as RNF86, is a 744 amino acid protein that localizes to cytoplasmic filaments and contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger, as well as one filamin repeat and six NHL repeats. Via its NHL repeats, TRIM2 interacts with Myosin V and is thought to contribute to the alternation of neural cellular mechanisms, possibly protecting cells from neurodegeneration. The gene encoding TRIM2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Description: Rabbit polyclonal to RNF86

Immunogen: KLH conjugated synthetic peptide derived from RNF86

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 81 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.