Background:  Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a multisubunit protein necessary for biogenesis of specialized organelles of the endosomal-lysosomal system (such as melanosomes and platelet-dense granules). The complex consists of coiled-coil-forming proteins Snapin, Pallidin, Cappuccino, Muted, BLOS1, BLOS2 and BLOS3. The localization of these proteins varies as they can be cytoplasmic, peripheral membrane bound or anchored to the vesicular membrane. Snapin associates with the SNARE complex in neurons. Phosphorylation of Snapin increases its interaction with SNAP25 and affects exocytotic protein interactions. Snapin interacts with the N-terminus of regulator of G protein signaling 7 (RGS7), which is important in synaptic vesicle exocytosis.

Description: Rabbit polyclonal to SNAPIN

Immunogen: KLH conjugated synthetic peptide derived from SNAPIN

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 15 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.