Background:  The deduced 1,134-amino acid Odin (ANKS1A) protein plays a putatuve negative role in growth factor receptor signaling pathways. Odin undergoes phosphorylation on tyrosine residues in response to growth factors EGF and PDGF, but not in response to cytokines, such as IL3 or erythropoietin. The PTB domain of Odin is not required for its tyrosine phosphorylation. Odin is a cytoplasmic protein before and after growth factor treatment, and is widely expressed at the protein level. Odin contains six ANK repeats, one PID domain, and two SAM (sterile alpha motif) domains. Overexpression of Odin inhibits EGF-induced activation of the FOS promoter. The gene which encodes Odin, ANKS1A, localizes to chromosome 6p21.31.

Description: Rabbit polyclonal to ANKS1A

Immunogen: KLH conjugated synthetic peptide derived from ANKS1A

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 123 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.