Background:  LPCAT2 is a 544 amino acid protein that belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. As a single-pass type II endoplasmic reticulum and Golgi apparatus membrane protein, LPCAT2 is involved in lipid and phospholipid metabolism. LPCAT2 has both acyltransferase and acetyltransferase activities that are calcium-dependent. LPCAT2 is known to play a role in PAF biosynthesis by catalyzing the conversion of the PAF precursor, lyso-PAF into PAF. LPCAT2 also has the ability to convert lyso-PAF to 1-alkyl-phosphatidylcholine (PC), which is a major component of cell membranes and a PAF precursor. During a resting state, LPCAT2 acyltransferase activity is preferred. Following acute inflammatory stimulus by LPS, acetyltransferase activity is enhanced and PAF synthesis increases.

Description: Rabbit polyclonal to LPCAT2

Immunogen: KLH conjugated synthetic peptide derived from LPCAT2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 60 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.