Background: LPHN2 is a member of the G protein-coupled receptors (GPCRs, or GPRs) family (subfamily Orphan-B). These receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. LPHN2 is a calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom, which triggers massive exocytosis from neurons and neuroendocrine cells. The receptor is implicated in the regulation of exocytosis. LPHN2 has been reported to be expressed in brain, breast, placenta, kidney, spleen, ovary, heart, and lung. ESTs have been isolated from a wide variety of tissue libraries.

Description: Rabbit polyclonal to LPHN2

Immunogen: KLH conjugated synthetic peptide derived from LPHN2

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 163 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.