Background:  Can mediate aggregation most likely through a homophilic molecular interaction. As a member of the immunoglobulin superfamily, ESAM (Endothelial cell-selective adhesion molecule) is a 390 amino acid junctional-type cellular adhesion protein that mediates homophilic reactions between endothelial cells. ESAM regulates endothelial permeability and angiogenesis and also participates in migration of neutrophils through the vessel wall by influencing endothelial cell contacts. After platelet activation, ESAM localizes to platelets in order to limit thrombus growth and stability, thereby optimizing the hemostatic response following vascular injury. This evidence suggests that ESAM may function as a mediator of atherosclerosis. Also, there is potential for ESAM to play a role in the regulation of tumor metastasis by promoting endothelial cell migration and tube formation in metastatic nodules.

Description: Rabbit polyclonal to ESAM

Immunogen: KLH conjugated synthetic peptide derived from ESAM

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 41 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.