Background:  Synaptotagmin XV (SytXV), also known as Synaptotagmin-15 (SYT15) or Chr10Syt, is a 421 amino acid single-pass type III membrane protein that belongs to the synaptotagmin family and contains two C2 domains. Both C2 domains are located on the C-terminal of Synaptotagmin XV and neither one mediates calcium-dependent or -independent phospholipid binding. Acting in non-neuronal tissues, Synaptotagmin XV may be involved in the trafficking and exocytosis of secretory vesicles. Synaptotagmin XV exists as four alternatively spliced isoforms that form homodimers. The gene that encodes Synaptotagmin XV contains 15,957 bases and maps to human chromosome 10q11.1. Making up nearly 4.5% of the human genome, chromosome 10 contains over 800 genes and 135 million nucleotides. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, Cockayne syndrome and porphyria.

Description: Rabbit polyclonal to Synaptotagmin 15

Immunogen: KLH conjugated synthetic peptide derived from Synaptotagmin 15

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 47 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.