Background:  Norpeg, also known as Ankycorbin or RAI14 (retinoic acid induced 14), is a 980 amino acid protein that localizes to the cytoplasm, the cytoskeleton and the cell cortex, and contains 7 ANK repeats. Expressed at high levels in testis, muscle and placenta, and at lower levels in liver, brain, lung, heart and intestine, Norpeg is thought to play a role in the maintenance and organization of the actin cytoskeleton. Norpeg exists as three alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 comprises about 6% of human genomic DNA. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm on chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Description: Rabbit polyclonal to RAI14

Immunogen: KLH conjugated synthetic peptide derived from RAI14

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 110 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.